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DOI: 10.1055/s-0031-1287665
The Need for Investigations to Elucidate Causes and Effects of Abnormal Uterine Bleeding
Publication History
Publication Date:
07 November 2011 (online)

ABSTRACT
This article describes a modern perspective on the basic investigations for abnormal uterine bleeding (AUB) in low-resource settings compared with a much more detailed approach for high-resource settings, bearing in mind issues of effectiveness and cost effectiveness. AUB includes any one or more of several symptoms, and it should be evaluated for the characteristics of the woman's specific bleeding pattern, her “complaint” and the presence of other symptoms (especially pain), the impact on several aspects of body functioning and lifestyle, and the underlying cause(s), especially cancer. Ideally, the evaluation is comprehensive, considering each of the potential etiological domains defined by the International Federation of Gynecology and Obstetrics PALM-COEIN system for the classification of causes. However, the detail of the questions and the extent of investigations will be significantly influenced by the technologies available and the time allotted for a consultation. In general, investigations should be performed only if they will make a material difference to the management approaches that can be offered. This should be an important consideration when a range of costly high-technology tests is accessible or when certain tests only have limited availability.
KEYWORDS
Abnormal uterine bleeding - heavy bleeding - investigations - imaging
REFERENCES
- 1
Fraser IS, Critchley HO, Broder M, Munro MG.
The FIGO recommendations on terminologies and definitions for normal and abnormal
uterine bleeding.
Semin Reprod Med.
2011;
29
(5)
383-390
Reference Ris Wihthout Link
- 2
Munro MG, Critchley HO, Broder MS, Fraser IS. FIGO Working Group on Menstrual Disorders .
The FIGO Classification System (“PALM-COEIN”) for causes of abnormal uterine bleeding
in non-gravid women of reproductive age.
Int J Gynaecol Obstet.
2011;
113
3-13
Reference Ris Wihthout Link
- 3
Munro MG, Critchley HO, Fraser IS.
The flexible FIGO classification concept for underlying causes of abnormal uterine
bleeding.
Semin Reprod Med.
2011;
29
(5)
391-399
Reference Ris Wihthout Link
- 4 O'Donovan PJ, Miller CE. Modern Management of Abnormal Uterine Bleeding. London, UK: Informa Healthcare; 2008
Reference Ris Wihthout Link
- 5 Munro MG. Abnormal Uterine Bleeding. Cambridge, UK: Cambridge University Press; 2010
Reference Ris Wihthout Link
- 6
Lieng M, Istre O, Sandvik L, Engh V, Qvigstad E.
Clinical effectiveness of transcervical polyp resection in women with endometrial
polyps: randomized controlled trial.
J Minim Invasive Gynecol.
2010;
17
(3)
351-357
Reference Ris Wihthout Link
- 7
Matteson K, Munro MG, Fraser IS.
The structured menstrual history: developing a tool to facilitate diagnosis and to
aid in symptom management.
Semin Reprod Med.
2011;
29
(5)
423-435
Reference Ris Wihthout Link
- 8
Santer M, Wyke S, Warner P.
What aspects of periods are most bothersome for women reporting heavy menstrual bleeding?
Community survey and qualitative study.
BMC Womens Health.
2007;
7
8
Reference Ris Wihthout Link
- 9
Fraser IS, Critchley HO, Munro MG, Broder M. Writing Group for this Menstrual Agreement Process .
A process designed to lead to international agreement on terminologies and definitions
used to describe abnormalities of menstrual bleeding.
Fertil Steril.
2007;
87
(3)
466-476
Reference Ris Wihthout Link
- 10
Rahn DD, Abed H, Sung VW et al..
Systematic review highlights difficulty interpreting diverse clinical outcomes in
abnormal uterine bleeding trials.
J Clin Epidemiol.
2011;
64
(3)
293-300
Reference Ris Wihthout Link
- 11
Warner PE, Critchley HO, Lumsden MA, Campbell-Brown M, Douglas A, Murray GD.
Menorrhagia II: is the 80-mL blood loss criterion useful in management of complaint
of menorrhagia?.
Am J Obstet Gynecol.
2004;
190
(5)
1224-1229
Reference Ris Wihthout Link
- 12 National Institute for Health and Clinical Excellence .Clinical Guideline 44; Heavy menstrual bleeding. Available at: http://www.nice.org.uk/nicemedia/pdf/CG44FullGuideline.pdf Accessed May 23, 2011
Reference Ris Wihthout Link
- 13
Matteson KA, Clark MA.
Questioning our questions: do frequently asked questions adequately cover the aspects
of women's lives most affected by abnormal uterine bleeding? Opinions of women with
abnormal uterine bleeding participating in focus group discussions.
Women Health.
2010;
50
(2)
195-211
Reference Ris Wihthout Link
- 14
Lukes AS, Muse K, Richter HE, Moore KA, Patrick DL.
Estimating a meaningful reduction in menstrual blood loss for women with heavy menstrual
bleeding.
Curr Med Res Opin.
2010;
26
(11)
2673-2678
Reference Ris Wihthout Link
- 15
Padilla LA, Radosevich DM, Milad MP.
Limitations of the pelvic examination for evaluation of the female pelvic organs.
Int J Gynaecol Obstet.
2005;
88
(1)
84-88
Reference Ris Wihthout Link
- 16
Trasi SA, Pathare AV, Shetty SD, Ghosh K, Salvi V, Mohanty D.
The spectrum of bleeding disorders in women with menorrhagia: a report from Western
India.
Ann Hematol.
2005;
84
(5)
339-342
Reference Ris Wihthout Link
- 17
Saxena R, Gupta M, Gupta PK, Kashyap R, Choudhry VP, Bhargava M.
Inherited bleeding disorders in Indian women with menorrhagia.
Haemophilia.
2003;
9
(2)
193-196
Reference Ris Wihthout Link
- 18
Kouides PA, Conard J, Peyvandi F, Lukes A, Kadir R.
Hemostasis and menstruation: appropriate investigation for underlying disorders of
hemostasis in women with excessive menstrual bleeding.
Fertil Steril.
2005;
84
(5)
1345-1351
Reference Ris Wihthout Link
- 19
Kadir RA, Chi C.
Women and von Willebrand disease: controversies in diagnosis and management.
Semin Thromb Hemost.
2006;
32
(6)
605-615
Reference Ris Wihthout Link
- 20
James AH, Kouides PA, Abdul-Kadir R et al..
Von Willebrand disease and other bleeding disorders in women: consensus on diagnosis
and management from an international expert panel.
Am J Obstet Gynecol.
2009;
201
(1)
12
e1-e8
Reference Ris Wihthout Link
- 21
Kadir RA, Economides DL, Sabin CA, Owens D, Lee CA.
Frequency of inherited bleeding disorders in women with menorrhagia.
Lancet.
1998;
351
(9101)
485-489
Reference Ris Wihthout Link
- 22
Abu JI, Habiba MA, Baker R et al..
Quantitative and qualitative assessment of women's experience of a one-stop menstrual
clinic in comparison with traditional gynaecology clinics.
BJOG.
2001;
108
(9)
993-999
Reference Ris Wihthout Link
- 23
Vercellini P, Cortesi I, De Giorgi O, Merlo D, Carinelli SG, Crosignani PG.
Transvaginal ultrasonography versus uterine needle biopsy in the diagnosis of diffuse
adenomyosis.
Hum Reprod.
1998;
13
(10)
2884-2887
Reference Ris Wihthout Link
- 24
Farquhar C, Ekeroma A, Furness S, Arroll B.
A systematic review of transvaginal ultrasonography, sonohysterography and hysteroscopy
for the investigation of abnormal uterine bleeding in premenopausal women.
Acta Obstet Gynecol Scand.
2003;
82
(6)
493-504
Reference Ris Wihthout Link
- 25
Grimbizis GF, Tsolakidis D, Mikos T et al..
A prospective comparison of transvaginal ultrasound, saline infusion sonohysterography,
and diagnostic hysteroscopy in the evaluation of endometrial pathology.
Fertil Steril.
2010;
94
(7)
2720-2725
Reference Ris Wihthout Link
- 26
Toth M, Patton DL, Esquenazi B, Shevchuk M, Thaler H, Divon M.
Association between Chlamydia trachomatis and abnormal uterine bleeding.
Am J Reprod Immunol.
2007;
57
(5)
361-366
Reference Ris Wihthout Link
- 27
Baerwald AR, Pierson RA.
Endometrial development in association with ovarian follicular waves during the menstrual
cycle.
Ultrasound Obstet Gynecol.
2004;
24
(4)
453-460
Reference Ris Wihthout Link
- 28
Emanuel MH, Verdel MJ, Wamsteker K, Lammes FB.
A prospective comparison of transvaginal ultrasonography and diagnostic hysteroscopy
in the evaluation of patients with abnormal uterine bleeding: clinical implications.
Am J Obstet Gynecol.
1995;
172
(2 Pt 1)
547-552
Reference Ris Wihthout Link
- 29
Schwärzler P, Concin H, Bösch H et al..
An evaluation of sonohysterography and diagnostic hysteroscopy for the assessment
of intrauterine pathology.
Ultrasound Obstet Gynecol.
1998;
11
(5)
337-342
Reference Ris Wihthout Link
- 30
Guido RS, Kanbour-Shakir A, Rulin MC, Christopherson WA.
Pipelle endometrial sampling. Sensitivity in the detection of endometrial cancer.
J Reprod Med.
1995;
40
(8)
553-555
Reference Ris Wihthout Link
- 31
Stovall TG, Ling FW, Morgan PL.
A prospective, randomized comparison of the Pipelle endometrial sampling device with
the Novak curette.
Am J Obstet Gynecol.
1991;
165
(5 Pt 1)
1287-1290
Reference Ris Wihthout Link
- 32
Ben-Baruch G, Seidman DS, Schiff E, Moran O, Menczer J.
Outpatient endometrial sampling with the Pipelle curette.
Gynecol Obstet Invest.
1994;
37
(4)
260-262
Reference Ris Wihthout Link
- 33
Dijkhuizen FP, Mol BW, Brölmann HA, Heintz AP.
The accuracy of endometrial sampling in the diagnosis of patients with endometrial
carcinoma and hyperplasia: a meta-analysis.
Cancer.
2000;
89
(8)
1765-1772
Reference Ris Wihthout Link
- 34
Nilsson L, Rybo G.
Treatment of menorrhagia.
Am J Obstet Gynecol.
1971;
110
(5)
713-720
Reference Ris Wihthout Link
- 35
Grimes DA.
Diagnostic dilation and curettage: a reappraisal.
Am J Obstet Gynecol.
1982;
142
(1)
1-6
Reference Ris Wihthout Link
- 36
Farquhar CM, Lethaby A, Sowter M, Verry J, Baranyai J.
An evaluation of risk factors for endometrial hyperplasia in premenopausal women with
abnormal menstrual bleeding.
Am J Obstet Gynecol.
1999;
181
(3)
525-529
Reference Ris Wihthout Link
- 37
Ash SJ, Farrell SA, Flowerdew G.
Endometrial biopsy in DUB.
J Reprod Med.
1996;
41
(12)
892-896
Reference Ris Wihthout Link
- 38
Gibson M.
Reproductive health and polycystic ovary syndrome.
Am J Med.
1995;
98
(1A)
67S-75S
Reference Ris Wihthout Link
- 39
Morgan RW.
Risk of endometrial cancer after tamoxifen treatment.
Oncology (Williston Park).
1997;
11
(2, Suppl 1)
25-33
Reference Ris Wihthout Link
- 40
Lu KH, Dinh M, Kohlmann W et al..
Gynecologic cancer as a “sentinel cancer” for women with hereditary nonpolyposis colorectal
cancer syndrome.
Obstet Gynecol.
2005;
105
(3)
569-574
Reference Ris Wihthout Link
- 41
Fraser IS, Critchley HO, Munro MG.
Abnormal uterine bleeding: getting our terminology straight.
Curr Opin Obstet Gynecol.
2007;
19
(6)
591-595
Reference Ris Wihthout Link
- 42
Vercellini P, Cortesi I, Oldani S, Moschetta M, De Giorgi O, Crosignani PG.
The role of transvaginal ultrasonography and outpatient diagnostic hysteroscopy in
the evaluation of patients with menorrhagia.
Hum Reprod.
1997;
12
(8)
1768-1771
Reference Ris Wihthout Link
- 43
Clark TJ.
Outpatient hysteroscopy and ultrasonography in the management of endometrial disease.
Curr Opin Obstet Gynecol.
2004;
16
(4)
305-311
Reference Ris Wihthout Link
- 44
Dueholm M, Lundorf E, Hansen ES, Ledertoug S, Olesen F.
Evaluation of the uterine cavity with magnetic resonance imaging, transvaginal sonography,
hysterosonographic examination, and diagnostic hysteroscopy.
Fertil Steril.
2001;
76
(2)
350-357
Reference Ris Wihthout Link
- 45
Huang GS, Gebb JS, Einstein MH, Shahabi S, Novetsky AP, Goldberg GL.
Accuracy of preoperative endometrial sampling for the detection of high-grade endometrial
tumors.
Am J Obstet Gynecol.
2007;
196
(3)
243
e1–e5
Reference Ris Wihthout Link
- 46
Krampl E, Bourne T, Hurlen-Solbakken H, Istre O.
Transvaginal ultrasonography sonohysterography and operative hysteroscopy for the
evaluation of abnormal uterine bleeding.
Acta Obstet Gynecol Scand.
2001;
80
(7)
616-622
Reference Ris Wihthout Link
- 47
Ossola MW, Bertulessi C, Iasi L et al..
Comparison of saline infusion sonography to transvaginal echography and hysteroscopy
in the diagnostic evaluation of abnormal uterine bleeding.
Int J Gynaecol Obstet.
1999;
11
145-150
Reference Ris Wihthout Link
- 48
Munro MG, Brooks PG.
Use of local anesthesia for office diagnostic and operative hysteroscopy.
J Minim Invasive Gynecol.
2010;
17
(6)
709-718
Reference Ris Wihthout Link
- 49
Mohan S, Page LM, Higham JM.
Diagnosis of abnormal uterine bleeding.
Best Pract Res Clin Obstet Gynaecol.
2007;
21
(6)
891-903
Reference Ris Wihthout Link
- 50
Marret H, Fauconnier A, Chabbert-Buffet N CNGOF Collège National des Gynécologues et Obstétriciens Français et al.
Clinical practice guidelines on menorrhagia: management of abnormal uterine bleeding
before menopause.
Eur J Obstet Gynecol Reprod Biol.
2010;
152
(2)
133-137
Reference Ris Wihthout Link
- 51
Chiang CH, Chang MY, Hsu JJ et al..
Tumor vascular pattern and blood flow impedance in the differential diagnosis of leiomyoma
and adenomyosis by color Doppler sonography.
J Assist Reprod Genet.
1999;
16
(5)
268-275
Reference Ris Wihthout Link
- 52
Perrot N, Frey I, Mergui JL, Bazot M, Uzan M, Uzan S.
Picture of the month. Adenomyosis: power Doppler findings.
Ultrasound Obstet Gynecol.
2001;
17
(2)
177-178
Reference Ris Wihthout Link
- 53
Mark AS, Hricak H, Heinrichs LW et al..
Adenomyosis and leiomyoma: differential diagnosis with MR imaging.
Radiology.
1987;
163
(2)
527-529
Reference Ris Wihthout Link
- 54
Bazot M, Cortez A, Darai E et al..
Ultrasonography compared with magnetic resonance imaging for the diagnosis of adenomyosis:
correlation with histopathology.
Hum Reprod.
2001;
16
(11)
2427-2433
Reference Ris Wihthout Link
- 55
Critchley HO, Warner P, Lee AJ, Brechin S, Guise J, Graham B.
Evaluation of abnormal uterine bleeding: comparison of three outpatient procedures
within cohorts defined by age and menopausal status.
Health Technol Assess.
2004;
8
(34)
iii-iv
1-139
Reference Ris Wihthout Link
- 56
Burton KA, Henderson TA, Hillier SG et al..
Local levonorgestrel regulation of androgen receptor and 17beta-hydroxysteroid dehydrogenase
type 2 expression in human endometrium.
Hum Reprod.
2003;
18
(12)
2610-2617
Reference Ris Wihthout Link
- 57
Timan IS, Tatsumi N, Aulia D, Wangsasaputra E.
Comparison of haemoglobinometry by WHO Haemoglobin Colour Scale and copper sulphate
against haemiglobincyanide reference method.
Clin Lab Haematol.
2004;
26
(4)
253-258
Reference Ris Wihthout Link
- 58
Eisenberg JM, Williams SV, Garner L, Viale R, Smits H.
Computer-based audit to detect and correct overutilization of laboratory tests.
Med Care.
1977;
15
(11)
915-921
Reference Ris Wihthout Link
- 59
Schroeder SA, Kenders K, Cooper JK, Piemme TE.
Use of laboratory tests and pharmaceuticals. Variation among physicians and effect
of cost audit on subsequent use.
JAMA.
1973;
225
(8)
969-973
Reference Ris Wihthout Link
- 60
Dixon RH, Laszlo J.
Ultilization of clinical chemistry services by medical house staff. An analysis.
Arch Intern Med.
1974;
134
(6)
1064-1067
Reference Ris Wihthout Link
- 61
Schoenenberger RA, Tanasijevic MJ, Jha A, Bates DW.
Appropriateness of antiepileptic drug level monitoring.
JAMA.
1995;
274
(20)
1622-1626
Reference Ris Wihthout Link
- 62
Deeks JJ.
Systematic reviews in health care: Systematic reviews of evaluations of diagnostic
and screening tests.
BMJ.
2001;
323
(7305)
157-162
Reference Ris Wihthout Link
- 63
Lijmer JG, Mol BW, Heisterkamp S et al..
Empirical evidence of design-related bias in studies of diagnostic tests.
JAMA.
1999;
282
(11)
1061-1066
Reference Ris Wihthout Link
- 64
van Dongen H, de Kroon CD, Jacobi CE, Trimbos JB, Jansen FW.
Diagnostic hysteroscopy in abnormal uterine bleeding: a systematic review and meta-analysis.
BJOG.
2007;
114
(6)
664-675
Reference Ris Wihthout Link
- 65
Matteson KA, Boardman LA, Munro MG, Clark MA.
Abnormal uterine bleeding: a review of patient-based outcome measures.
Fertil Steril.
2009;
92
(1)
205-216
Reference Ris Wihthout Link
- 66
Hallberg L, Nilsson L.
Determination of menstrual blood loss.
Scand J Clin Lab Invest.
1964;
16
244-248
Reference Ris Wihthout Link
- 67
Hoppe-Seyler G, Broderson A, Rudolph A.
Uber den Blutverlist bei der menstruation [in German].
Ztschr F Physiol Chem..
1904;
42
545-553
Reference Ris Wihthout Link
- 68
Fraser IS, McCarron G, Markham R.
A preliminary study of factors influencing perception of menstrual blood loss volume.
Am J Obstet Gynecol.
1984;
149
(7)
788-793
Reference Ris Wihthout Link
- 69
Magnay JL, Nevatte TM, Dhingra V, O'Brien S.
Menstrual blood loss measurement: validation of the alkaline hematin technique for
feminine hygiene products containing superabsorbent polymers.
Fertil Steril.
2010;
94
(7)
2742-2746
Reference Ris Wihthout Link
- 70
Fraser IS, McCarron G, Markham R, Resta T.
Blood and total fluid content of menstrual discharge.
Obstet Gynecol.
1985;
65
(2)
194-198
Reference Ris Wihthout Link
- 71
Fraser IS, Warner P, Marantos PA.
Estimating menstrual blood loss in women with normal and excessive menstrual fluid
volume.
Obstet Gynecol.
2001;
98
(5 Pt 1)
806-814
Reference Ris Wihthout Link
- 72
Reid PC.
Assessment of menorrhagia by total menstrual fluid loss.
J Obstet Gynaecol.
2006;
26
(5)
438-441
Reference Ris Wihthout Link
- 73
Higham JM, O'Brien PM, Shaw RW.
Assessment of menstrual blood loss using a pictorial chart.
Br J Obstet Gynaecol.
1990;
97
(8)
734-739
Reference Ris Wihthout Link
- 74
Reid PC, Coker A, Coltart R.
Assessment of menstrual blood loss using a pictorial chart: a validation study.
BJOG.
2000;
107
(3)
320-322
Reference Ris Wihthout Link
Malcolm G MunroM.D.
Department of Obstetrics and Gynaecology, David Geffen School of Medicine at UCLA,
Kaiser Permanente, Los Angeles Medical Center
Station 3-B, 4900 Sunset Boulevard, Los Angeles, CA 90027
Email: mmunro@ucla.edu